Abstract: To increase yield and improve quality of flue-cured tobacco in panzhihua tobacco growing area, experiments were carried out to study the effects of organic potassium fertilizer on the yield and quality of flue-cured tobacco in panzhihua. The results showed that the fertilizers could regulate the development and metabolism of tobacco plants. The potassium content significantly increased by 14.3%-36.0% and the chemical composition was more coordinate after applying the fertilizer. The appearance quality was improved. The highest yield of 3907.91 yuan/667 m² was observed in treatment with humic acid compound fertilizer and organic potassium fertilizers.