Abstract: In order to definite the role of Guizhou mountainous bouquet & sweet tobacco in cigarette formula, representative formulation groups of seven different areas and foreign medium aroma areas were added to the original seven different styles of representative mainstream cigarette brands to optimize leaf formula. The results showed that Guizhou mountainous bouquet & sweet formulation leaf groups had good suitability to mainstream cigarette brands, most of the formulation leaf groups could improve the brand cigarette quality, maintain and highlight the cigarette style features. To specific cigarette brands had great regional expansion of space and on the basis of existing formula can increase the dosage; Meitan, Weng'an, Zunyi and Shibing leaf groups in the cigarette formula had a better blendinge effect, and between each big brand cigarette can be a very good fusion. Bijie, Changshun, Sinan leaf groups were relatively weak, exhibiting a certain compatibility with some cigarette brands.