Abstract: Tobacco (Nicotiana tabacum L.)is an economic crop in which mature yellow leaves are harvested. Leaf maturity and the ripening process have a decisive influence on the quality of tobacco products. In this article we briefly introduce the research progress of plant leaf senescence related genes. We also summarize the research progress in genes related to tobacco leaf senescence and the effects of exogenous genes on the senescence of tobacco. It is of great importance to study tobacco leaf senescence process and related genes in order to improve the quality of tobacco.