Abstract: The aim of this study is to investigate the effects of chemical components on smoking quality of flue-cured tobacco. Yunyan 87, a flue-cured tobacco variety, was selected as materials to study the correlation between the main chemical components and smoking quality of tobacco by using the method of canonical correlation analysis. The results showed that for Chongqing tobacco, sugar content was relatively high, the contents of nicotine, total nitrogen and starch were appropriate, the contents of potassium and chloride were low. The difference of total sugar and reducing sugar, ratio of reducing sugar to nicotine were relatively high. The ratios of reducing sugar to total sugar and potassium to chloride were appropriate. The ratio of nitrogen to nicotine was low. The canonical correlation analysis showed that the strength had positive correlation with total nitrogen, nicotine, and had negative correlation with the ratio of reducing sugar to nicotine. The irritancy had certain correlation with chemical components, with the effect of potassium and the ratio of reducing sugar to nicotine being positive, while the effect of total nitrogen and nicotine being negative. Sweetness was significantly negatively correlated with starch, while the ratio of reducing sugar was opposite. The permeability had significant negative correlation with starch. Therefore, it is believed that sugar, total nitrogen, nicotine, potassium and starch are the key factors affecting the sensory quality of Chongqing flue-cured tobacco.