Abstract: In order to mitigate the white pollution caused by film cover in tobacco fields, a field plot experiment was conducted in 2018 to explore the feasibility of replacing conventional plastic film with oxo-biodegradation plastic film. Five treatments including conventional plastic film (CK0), timely uncovering treatments (CK1), oxo-biodegradable films A (T1), oxo-biodegradable films B (T2), oxo-biodegradable films C (T3) were set to investigate the effects of different mulching treatments (0-10 cm soil layer and 10-20 cm soil layer) on soil moisture, soil temperature, growth and development of flue-cured tobacco and its economic benefits. The results showed that all the degraded films were degraded during the tobacco growing period, and the degraded films of the T3 treatment entered the cracking and large cracking period 22 d and 39 d after transplanting, with later cracking time and lower cracking degree than those of the T1 and T2 treatments. 0-35 d after transplanting, the soil temperature and water content under the degradation film of the T3 treatment were higher than those of the T1 and T2 treatments, and the effect of temperature and moisture conservation was close to that of the CK0. 35 days after transplantation, the degraded film of the T3 treatment still had some insulation effect compared with CK1.Tobacco plant growth in different periods and economic benefits under the T3 treatment was better than that of the T1 and T2 treatments, and was similar to those under CK0 and CK1. Therefore, it is feasible to replace conventional mulch with degradable mulch that has a low degree of cracking before tobacco rosette stage leaves and can be fully degraded during the tobacco growing period.