Abstract: For evaluating tobacco varieties better in brand-oriented tobacco base units, 10 flue-cured tobacco varieties planted in Ningxiang, Hunan Province, were comprehensively evaluated by using DTOPSIS method in terms of economic traits, chemical composition and physical property. The results showed that the order of comprehensive evaluation value was: Zhongyan 100 > K326 > NX232 > Yunyan97 > Xiangyan3 > Y892 > Yunyan87 > NC55 > NC297 > NC89. DTOPSIS was an effective tool for comprehensive evaluation on tobacco varieties.