Abstract: In order to provide a scientific basis for optimal potassium fertilizer types and topdressing depth to increase tobacco production, a field experiment was conducted to study the effects of different potassium fertilizer types and topdressing depth on the yield, benefit and nutrient uptake of tobacco by using split plot design with potassium fertilizer (two levels) as main treatment and dressing depths (three levels) as sub-plots. The results showed that, different potassium fertilizer, topdressing depth and their interactions had a significant effect on tobacco yield, economic value and nutrients uptake. In the same topdressing depth, compared with potassium sulfate, applying coated potassium fertilizer increased the yield and output value of tobacco, and increased by 10.6% to 15.2% and 11.0% to 18.2% respectively; Applying the same potassium fertilizer, topdressing the potassium fertilizer 20 cm effectively increased the economic benefit than 10 cm, for applying coated potassium fertilizer, topdressing depth 20 cm increased potassium, phosphorus, zinc and sulfur content in middle leaves and upper leaves than 10 cm, however. For potassium fertilizer types and potassium fertilizer types/topdressing depth interaction effect, topdressing bio-oil coated potassium fertilizer 20 cm treatment is the best, the second is topdressing humic acid coated potassium fertilizer 20 cm treatment. Under this experimental conditions, deep application coated potassium fertilizer in 20 cm soil layer can make full use of the topdressing depth and types of potassium fertilizer interaction effect, and effectively improve tobacco yield, economic benefits and potassium utilization efficiency.