Abstract: Controlled release fertilizers (CRF) have been widely applied in agricultural production, but there is a shortage in special CRFs for tobacco at present. Field experiments were conducted to study the effects of special CRFs for tobacco on yield, appearance quality, chemical composition, nutrient use efficiency and plant disease incident rate of tobacco in two years. The results showed that, compared with local recommended fertilization, the special CRFs enhanced the resistance of tobacco plants to diseases, increased yield by 1.8%-15.7%, and improved NPK use efficiency by 6.7%-14.8%, 3.4%-11.4% and 4.3%-7.1%, respectively. Meanwhile, the special CRFs promoted appearance quality of tobacco, increased the fine tobacco ratios by 0.8-5.8 percentage point, raised reducing sugar and total sugar contents, reduced total nitrogen and alkaloid contents in the upper and lower tobacco leaves, and increased K content in the middle tobacco leaves. Furthermore, application of the special CRFs significantly increased economic benefit. The results indicated that the special CRFs showed an excellent comprehensive effect and could be popularized and applied in tobacco production.