Abstract: To investigate the control effect of seaweed polysaccharides and some organic materials on the tobacco bacterial wilt, a field experiment was performed using flue-cured tobacco variety NC102 as the experimental material. A series of experimental trials was designed including seaweed polysaccharides only, and combination of seaweed polysaccharides with organic materials including microbial fertilizer, plant ash, shells powder and biochar. The effect of different treatment on the tobacco agronomic and economic traits, the soil physi-chemical properties, the flue-cured tobacco chemical composition, and the correlations between soil physi-chemical properties and the incidence and disease index of tobacco bacterial wilt were analyzed. The results showed that, compared with the control, the application of seaweed polysaccharides and organic materials generally promoted the growth and development of tobacco during the resetting stage and vigorous growing stage, increased the soil pH and organic matter content, reduced the incidence and disease index of tobacco bacterial wilt, and improved the economic characteristics and the main chemical components of flue-cured tobacco leaves. Pearson correlation analysis showed that there were significantly negative correlations between soil organic matter content, soil pH and the incidence and disease index of bacterial wilt. Application of 500 times diluted polysaccharide with 50~100 mL/plant showed a negative correlation with the incidence index of bacterial wilt, whereas plant ash+seaweed polysaccharide 75 mL/plant treatment showed the best control effect of bacterial wilt in all treatments. Therefore, the occurrence of bacterial wilt can help controlled by adding seaweed polysaccharides and organic materials to adjust soil pH and soil organic matter content.