Abstract: In order to explore the suitable water and fertilizer management in areas with incoordination between rainfall distribution and water demand for flue cured tobacco growth, field experiments were carried out to study the effects of water supply under film and ridging height, fertilization times and fertilizer types on growth, yield and quality of flue-cured tobacco. The results showed that, compared with drip irrigation, the soil water content of the inclined 5-hole micro spraying treatment was significantly increased, the comprehensive index value of chemical composition was increased by 22.50%-34.00%, the aroma quality was improved and the comprehensive score of sensory evaluation was increased by 2-4, which significantly reduced the labor cost and increased the income of tobacco farmers; Increasing the ridging height by 3-5 cm on the basis of standard ridge height (32-35 cm) could significantly increase the maximum leaf length and width, the yield of flue-cured tobacco, the income of tobacco farmers and the comprehensive index value of chemical composition of tobacco leaves (p<0.05). Under the conditions of high ridge and micro spray irrigation under plastic film, compared with fractional fertilization, for the treatments of one-time fertilization with increased slow release organic-inorganic compound fertilizer, tobacco yield and the comprehensive index value of chemical composition of middle tobacco was increased by 3.42%-14.98% and 34.04%-40.82% respectively. In summary, Micro spraying under film+deep planting in high ridge + no uncovering film and soil filling+slow-release organic-inorganic compound fertilizer was a suitable water and fertilizer management mode for tobacco areas with uneven rainfall distribution in Guangyuan, Sichuan.