Abstract: To analyze the influence of main chemical indices of flue-cured tobacco on overall sensory coziness. 35 tobacco chemical indices in 50 domestic and imported representative tobacco leaves were analyzed and verified. Meanwhile, a comprehensive sensory coziness evaluation was conducted on the 50 samples. The data of chemical indicators and sensory evaluation were analyzed by multiple correlation coefficient method. The results showed that: nicotine, ratio of N to nicotine, the ratio of reducing sugar to nicotine, petroleum ether extracts and sensory comfort as a whole was significantly related (P < 0.05). Other chemical parameters and sensory coziness of 10 indice correlation scores were not statistically significant (P > 0.05). According to the multiple correlation coefficient and significance level, the specific influence degree order of main chemical components of tobacco on the sensory comfort was nicotine > ratio of N to nicotine > the ratio of reducing sugar to nicotine > petroleum ether extract.