Abstract: In order to select elite flue-cured tobacco varieties which adapted to specific ecological conditions in Henan, the stability and adaptation were analyzed with AMMI model. The data of 7 varieties (lines) were obtained from 4 experimental areas of flue-cured tobacco regional trial in Henan province. The results showed that the yield of 7 cultivars were in suitable range. The average price and the rate of grade A cured leaves showed significant variation at different locations. Line Y102 had the highest yield, value, average price and the rate of grade A cured leaves, with good adaptation to specific environment; Y106 had better economic characters and adaptability. The average price and the rate of grade A cured leaves of H8190 were lower than the control NC89, while the yield and stability was better; the economic traits of Youxuan1 was better than control, while 8182 and 8122 were lower than control. There was significant G×E interaction for total score of smoking quality among different varieties (lines). Y102 and Y106 had better smoking quality under different locations.