Abstract: In order to investigate the appropriation of the main chemical components in central Henan tobacco growing areas, the main chemical components in different leaf grades of 4 consecutive years from central Henan in different tobacco growing areas were analyzed and comprehensively evaluated. The results showed that there were significant differences between contents of total sugar, reducing sugar, nicotine, the ratio of total sugar to nicotine and the ratio of total nitrogen to nicotine among different grades of tobacco leaves, but there were not significant differences in the contents of protein, chlorine, potassium and the ratio of potassium to chlorine. The main chemical components in different growing areas were not significant, but were significant difference in different years. The contents of total sugar, reducing sugar, nicotine, the ratio of total sugar to nicotine and the ratio of total nitrogen to nicotine in tobacco leaves were medium. The contents of potassium and the ratio of potassium to chlorine were low. The contents of chlorine and protein were high. The comprehensive evaluation of chemical components was about 62.5% at the middle level, and 37.5% at the low level with an average of 0.62. The low contents of potassium and the ratio of potassium to chlorine, the high contents of chlorine and protein were the main factors which affected the availability of central Henan flue-cured tobacco leaf. The flue-cured tobacco leaf of different areas of central Henan in the same year can be blended in the process of Leaf redrying and the stability of production needs to be improved.