SiRNA介导的基因沉默及其在植物抗病毒应用中的研究进展

SiRNA Induced Gene Silencing and Its Application in Plant Anti-virus

摘要: 基因沉默是由双链RNA介导的同源RNA的降解现象，是一种古老的RNA监控系统，协助生物体抵抗外来核酸的入侵。基因沉默系统是植物抵抗病毒侵染的防卫体系，在长期的协同进化过程中，由病毒编码的抑制蛋白可以抵消基因沉默系统的作用。本文对基因沉默的过程、病毒编码的抑制子蛋白及基因沉默在植物抗病毒工程的研究进展进行简要综述。

Abstract: Gene silencing is a phenomenon of homologous RNA degradation, which might have arisen as an ancient RNA surveillance system that acts as a natural defense mechanism against invasive nucleic acids. From long period evolution with plants, plant virus obtains the ability to code gene silencing suppressors against this defense system. This paper reviewed the advancement of gene silencing mechanism, silencing suppressors coded by virus, and the application of gene silencing in plant anti-virus engineering.