Abstract: The main tobacco aggressive diseases in west region of Fujian Province are anthracnose, virus disease (including tobacco mosaic virus, cucumber mosaic virus, potato virus Y, tobacco ringspot virus, tobacco etch virus, tobacco leaf curl virus ), black shank, brown spot, bacterial wilt. The tobacco nonaggressive diseases includ weather fleck and nutrient deficiency. The comprehensive measures on the control of tobacco disease accordinging to local ecological conditions and the results of concerned experiments and demonstrations were suggested.