Abstract: Flavor is a key determinant of tobacco quality and characterization. In this paper, the research status of the tobacco flavor is systematically reviewed through comprehensive literature research and data visualization analysis. Additionally, combined with the interpretation of the connotation of scientific research on tobacco flavor, future development trends as well as the challenges faced by the tobacco flavor study were summarized and looked forward, aiming to provide ideas and references for the improvement of tobacco product flavor quality based on flavor engineering technology, for the modulation of biological effects of tobacco flavor based on the theory of flavor brain science, and for the development of special tobacco products and novel applications.