Abstract: A series of assessments on ecological adaptability of flue-cured tobacco were conducted in order to properly identify the best planting regions of flue-cured tobacco in Shandong province, China. The assessment used 29 factors as adaptability indices, including air temperature, ≥10 ℃ accumulated airtemperature, sunshine hours, and humidity during field growth; annual precipitation during root extending, vigorous growth, and maturing periods; andtemperature difference between day and night; soil pH, OM, soil soluble Cl, total N, P, K, available N, P, K, Ca, Mg, S, Fe, Mn, Zn, Cu, Mo; terrain,altitude, degree of slope, and soil type. The fuzzy logic, analytic hierarchy process, and arcGis were employed to classify and evaluate these indices. Theresults showed that, in Shandong, climatic suitability for flue-cured declined from the South to North, Too many sunshine hours during field growth period was the primarily climatic factor influencing the growth of flue-cured in Shandong. Soil nutrients were sufficient for the tobacco growth in Shandong. The terrain in Shandong was very suitable to the growth of flue-cured tobacco. Some of the soils along the seashore in Shandong was unfavorable to the growth of the flue-cured tobacco. Most of the current tobacco plantings were located in the most suitable or suitable regions in Shandong. The study is significant forproper planning and producing better flue-cured tobacco leaves at the lowest cost. The methods used in this study provided the greatest accuracies inassessing complicated influence factors on crops and can be effectively applied to other crops and regions.