Abstract: Tobacco-area industrial complexes (abbreviated as “the Complex”) serve as pivotal platforms for driving modernization in tobacco agriculture and facilitating integrated development between tobacco and grain industries. This paper establishes a logical framework based on the general principles of modern tobacco agriculture development, modern agricultural advancement, and modern industrial system construction, elucidating the approach to build such complexes. Based on practical experience in agricultural industrialization and modern tobacco agriculture, combined with case studies, this paper expounds and summarizes the implementation pathways of such complexes at different developmental stages. This study summarizes the development achievements of the Complex in terms of its industrial development foundation, business entities, system resilience, and competitive capabilities. It further proposes that the next phase should focus more on the content and quality of the Complex development, deepen integrated clusters combining grain, tobacco, economic crops, and explore the establishment of modernized tobacco agriculture collaborative development zones based on the existing complex, enhancing its exemplary, leading, and driving role in regional development.